This study assessed the effectiveness of AI-Powered Apps on health information dissemination among academic staff of Prince Abubakar Audu University, Anyigba. AI-Powered Health Apps represents a prominent example of AI-powered technology in the healthcare domain, offering personalized health advice and information to users. This study aims to explore how these apps impact the delivery of health information among the respondents. The study adopted Technology Determinism theory as the theoretical framework. The study adopted quantitative survey design to gather data from 200 out of 364 members of academic staff of Prince Abubakar Audu University, Anyigba using purposive and convenient sampling techniques. The researchers analyzed data regarding the level of awareness, adoption, and the effectiveness of AI-Powered Apps for health information. The findings of the study revealed a growing awareness of AI-powered health information apps. However, the ability to name specific apps was lower, highlighting the need for increased education and outreach about available resources. The study revealed a moderate adoption of AI health information apps among the respondents. There was also a positive perception of the apps’ accuracy, knowledge acquisition benefits, and user-friendliness. The study recommended that Prince Abubakar Audu University should organize workshops or seminars to educate academic staff about the potential of AI-powered health information apps. Keywords: Artificial Intelligence, AI-powered apps, Health information, Effectiveness.